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赤松　美紀・業績一覧

赤松　美紀准教授研究業績／主要論文・著書(2000年～2005年）

著書・総説

  • 赤松美紀：内分泌攪乱性化学物質の構造活性相関, JCPE Journal, 13, 13-20 (2001)
  • 赤松美紀：農薬の三次元構造活性相関に関する研究．日本農薬学会誌，27，169-178(2002)
  • Akamatsu, M.: Current state and perspectives of 3D-QSAR. Current Topics in Med. Chem., 2, 1381-1394 (2002)
  • Ano, R., Kimura, Y., Shima, M., Matsuno, R., and Akamatsu, M.: Relationship between Structure and Permeability of Oligopeptides and Related Compounds. In Peptide Science 2002(Ed. T. Yamada), The Japanese Peptide Society, pp. 233-234 (2003)
  • Akamatsu, M., Ano, R., Kimura, Y., Shima, M., and Matsuno, R: Relationship between structure and permeability of oligopeptide derivatives and related compounds. In Designing Drugs and Crop Protectants: processes, problems, and solutions (Proceedings of the 14th EuroQSAR 2002 Symposium) (Eds. Ford, M., Livingstone, D., Dearden, J., and Waterbeemd, H. van de), Blackwell Publishing, Oxford, pp. 224-225 (2003).
  • Yamagami, C., Motohashi, N., Emoto, T., Tanahashi, T., Nagakura, N., Akamatsu, M., and Takeuchi, Y.: Quantitative structure-activity relationship analyses of antioxidative hydroxybenzalacetones. In Designing Drugs and Crop Protectants: processes, problems, and solutions (Proceedings of the 14th EuroQSAR 2002 Symposium) (Eds. Ford, M., Livingstone, D., Dearden, J., and Waterbeemd, H. van de), Blackwell Publishing, Oxford, pp. 471-472 (2003).
  • Mizokami, S., H. Tamamura, K. Hiramatsu, M. Mizumoto, M. Akamatsu, H. Nakashima, Z. Wang, S.C. Peiper, N. Yamamoto, A. Otaka and N. Fujii: New leads of low molecular weight CXCR4 antagonists based on enhancement of the T140-based pharmacophores. Peptide Science 2003(Ed. M. Ueki), pp. 285-288, The Japanese Peptide Society, Tsukuba, (2004)
  • Miyashita, M., T.Shimada, S. Nakagami, N. Kurihara, H. Miyagawa and M. Akamatsu: Evaluation of estrogen receptor binding affinity of DDT-related compounds and their metabolites. Environmental Fate and Safety Management of Agrochemicals (Eds. J.M. Clark, and H. Ohkawa), pp. 159-166, American Chemical Society, Washington, DC, (2005)
  • Akamatsu, M., Fujikawa, M., Ano, R., Nakao, K., and Shimizu, R.: Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability. In QSAR & Molecular Modelling in Rational Design of Bioactive Molecules (Proceedings of the 15th EuroQSAR 2004 Symposium) (Eds. Aki, E. and Yalcin, I.), Baskent Klise ve Matbaacilik, Ankara, pp. 166-167 (2006)
  • 赤松美紀：Classical および三次元構造活性相関手法による薬物動態解析, 創薬動態, 日本薬物動態学会，pp. 315-319 (2006)
  • Tamura, H., Hosoda, A., and Akamatsu, M.: Endocrine disruptors that disrupt the transcription mediated by androgen receptor. J. Pestic. Sci., 33, 33-39 (2008)
  • 赤松美紀，藤川真章，中尾和也，清水　良：環境中に存在する化学物質のヒト経口吸収性を予測する，化学と生物, 46, 194-199 (2008)
     

原著論文

  • Ozoe, Y. and Akamatsu, M.: Molecular interactions of non-competitive antagonists with ionotropic g-aminobutyric acid receptors: studies into species difference. In Agrochemical Discovery (Ed. D.R. Baker and N.K. Umetsu), American Chemical Society, Washington, DC, pp. 256-268 (2001)
  • Shimomura, M., Okuda, H., Matsuda, K., Komai, K., Akamatsu, M., and Sattelle, D.B.: Effects of mutations of a glutamine residue in loop D of the a7 nicotinic acetylcholine receptor on agonist profiles for neonicotinoid insecticides and related ligands. British J. Pharm., 137, 162-169 (2002)
  • Yamagami, C., Motohashi, N., and Akamatsu, M.: Quantum chemical- and 3-D-QSAR (CoMFA) studies of benzalacetones and 1,1,1-trifluoro-4-phenyl-3-buten-2-ones. Bioorg. Med. Chem. Lett., 12, 2281-2285 (2002)
  • Miyashita, M., Nakamori, T., Miyagawa, H., Akamatsu, M., and Ueno, T.: Inhibitory activity of analogs of AM-toxin, a host-specific phytotoxin from the Alternaria alternata apple pathotype, on photosynthetic O2 evolution in apple leaves. Biosci. Biotechnol. Biochem., 67, 635-638 (2003)
  • Ihara, M., Matsuda, K., Otake, M., Kuwamura, M., Shimomura, M., Komai, K., Akamatsu, M., Raymond, V. and Sattelle, D.V.: Diverse actions of neonicotinoids on chicken ?7, ?4?2 and Drosophila – chicken SAD?2 and ALS?2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes, Neuropharmacology, 45, 133-144 (2003).
  • Shimomura, M., Yokota, M., Okumura, M., Matsuda, K., Akamatsu, M., Sattelle, D.B., and Komai, K.: Combinatorial mutations in loops D and F strongly influence responses of the ?7 nicotinic acetylcholine receptor to imidacloprid. Brain Res., 991, 71-77 (2003).
  • Tamamura, H., Hiramatsu, K.,, Mizumoto, M., Ueda, S., Kusano, S., Terakubo, S., Akamatsu, M., Yamamoto, N., Trent, J.O., Wang, Z., Peiper, S.C., Nakashima, H., Otaka, A., and Fujii, N.: Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org. Biomol. Chem., 1, 3663-3669 (2003).
  • Wheelock, C.E., Nakagawa, Y., Akamatsu, M., and Hammock, B.D.: Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. Bioorg. Med. Chem., 12, 5101-5116 (2003).
  • Miyashita, M., T. Shimada, S. Nakagami, N. Kurihara, H. Miyagawa. and M. Akamatsu: Enantioselective Recognition of Mono-demethylated methoxychlor metabolites by the estrogen receptor. Chemosphere 54, 1273-1276, 2004
  • Ano, R., Y. Kimura, M. Urakami, M. Shima, R. Matsuno, T. Ueno and M. Akamatsu: Relationship between structure and permeability of dipeptide derivatives containing Tryptophan and related compounds across human intestinal epithelial (Caco-2) cells. Bioorg. Med. Chem. 12, 249-255, (2004)
  • Ano, R., Y. Kimura, M. Shima, R. Matsuno, T. Ueno and M. Akamatsu: Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability. Bioorg. Med. Chem. 12, 257-264, (2004)
  • Wanchana, S, F. Yamashita, H. Hara, S. Fujiwara, M. Akamatsu and M. Hashida: Two- and three-dimensional QSAR of carrier-mediated transport of -lactam antibiotics in Caco-2 cells. J. Pharm. Sci. 93, 3057-3065, (2004)
  • Miyashita, M., T. Shimada, H. Miyagawa and M. Akamatsu: Surface plasmon resonance-based immunoassay for 17 estradiol and its application to the measurement of estrogen receptor-binding activity. Anal. Bioanal. Chem. 381; 666-673, (2005)
  • Yamagami, C., M. Akamatsu, N. Motohashi, S. Hamada and T. Tanahashi: Quantitative structure activity relationship studies for antioxidant hydroxybenzalacetones by quantum chemical and 3-D-QSAR (CoMFA) analyses. Bioorg. Med. Chem. Lett. 15; 2845-2850, (2005)
  • Fujikawa, M., R. Ano, K. Nakao, R. Shimizu, and M. Akamatsu: Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability. Bioorg. Med. Chem. 13; 4721-4732, (2005)
  • Yamamoto, S., Watanabe, B., Otsuki, J., Nakagawa, Y., Akamatsu, M, and Miyagawa, H.: Synthesis of 26, 27-bisnorcastasterone analogs and analysis of conformation-activity relationship for brassinolide-like activity. Bioorg. Med. Chem., 14, 1761-1770 (2006).
  • Wheelock, C.E., Nakagawa, Y., Harada, T., Oikawa, N., Akamatsu, M., Smagghe, G., Stefanou, D., Iatrou, K., and Swevers, L.: High-throughput screening of ecdyson agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity. Bioorg. Med. Chem., 14, 1143-1159 (2006).
  • Minakuchi, C., Suzuki, J., Toda, K., Akamatsu, M., and Nakagawa, Y.: Estimation of the hydrophobicity of 2,4-diphenyl-1,3-oxazoline analogs and QSAR analysis of their ovicidal activity against Tetranycus urticae. Bioorg. Med. Chem. Lett., 16, 4080-4084 (2006).
  • Tamura, H., Ishimoto, Y., Fujikawa, T., Aoyama, H., Yoshikawa, H., and Akamatsu, M.: Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR. Bioorg. Med. Chem., 14, 7160-7174 (2006).
  • Shimomura, M., Yokota, M., Ihara, M., Akamatsu, M., Sattelle, D.B., and Matsuda, K.: Role in the selectivity of neonicotinoids of insect-specific basic residues in loop D of the nicotinic acetylcholine receptor agonist binding site. Mol. Pharmacol., 70, 1255-1263 (2006).
  • Fujikawa, M., Nakao, K., Shimizu, R., and Akamatsu, M.: QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorg. Med. Chem., 15, 3756-3767 (2007).
  • Tomita, K., Oishi, S., Cluzeau, J., Ohno, H., Navenot, J.-M., Wang, Z., Peiper, S.C., Akamatsu, M., and Fujii, N.: SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54. J. Med. Chem., 50, 3222-3228 (2007).
     
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