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Miki Akamatsu

  • Graduate School, Faculty of Agriculture, Kyoto University
  • Division of Environmental Science and Technology
  • Comparative Agricultural Science
  • 〒606-8502　Oiwakecho, Kitasirakawa, Sakyo-Ku, Kyoto City, Kyoto, Japan
  • TEL&FAX：075-753-6489
  • e-mail：akamatsu [atmark] kais.kyoto-u.ac.jp

Research Activities

  • Key Words

Quantitative Structure-Activity Relationships (QSAR)／Pesticide／Environment／Drug-design

Main subjects

 

  • Fujikawa, M., Ano, R., Nakao, K., Shimizu, R., and Akamatsu, M.: Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability. Bioorg. Med. Chem., 13, 4721-4732 (2005)
  • Wheelock, C.E., Nakagawa, Y., Harada, T., Oikawa, N., Akamatsu, M., Smagghe, G., Stefanou, D., Iatrou, K., and Swevers, L.: High-throughput screening of ecdyson agonists using a reporter gene assay followed by 3-D QSAR analysis of the molting hormonal activity. Bioorg. Med. Chem., 14, 1143-1159 (2006)
  • Akamatsu, M., Fujikawa, M., Ano, R., Nakao, K., and Shimizu, R.: Relationships between structure and high-throughput screening permeability of diverse drugs with artificial membranes: application to prediction of Caco-2 cell permeability. In QSAR & Molecular Modelling in Rational Design of Bioactive Molecules (Proceedings of the 15th EuroQSAR 2004 Symposium) (Eds. Aki, E. and Yalcin, I.), Baskent Klise ve Matbaacilik, Ankara, pp. 166-167 (2006)
  • Minakuchi, C., Suzuki, J., Toda, K., Akamatsu, M., and Nakagawa, Y.: Estimation of the hydrophobicity of 2,4-diphenyl-1,3-oxazoline analogs and QSAR analysis of their ovicidal activity against Tetranycus urticae. Bioorg. Med. Chem. Lett., 16, 4080-4084 (2006)
  • Tamura, H., Ishimoto, Y., Fujikawa, T., Aoyama, H., Yoshikawa, H., and Akamatsu, M.: Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR. Bioorg. Med. Chem., 14, 7160-7174 (2006)
  • Shimomura, M., Yokota, M., Ihara, M., Akamatsu, M., Sattelle, D.B., and Matsuda, K.: Role in the selectivity of neonicotinoids of insect-specific basic residues in loop D of the nicotinic acetylcholine receptor agonist binding site. Mol. Pharmacol., 70, 1255-1263 (2006)
  • Fujikawa, M., Nakao, K., Shimizu, R., and Akamatsu, M.: QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorg. Med. Chem., 15, 3756-3767 (2007)
  • Tomita, K., Oishi, S., Cluzeau, J., Ohno, H., Navenot, J.-M., Wang, Z., Peiper, S.C., Akamatsu, M., and Fujii, N.: SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54. J. Med. Chem., 50, 3222-3228 (2007)
  • Tamura, H., Hosoda, A., and Akamatsu, M.: Endocrine disruptors that disrupt the transcription mediated by androgen receptor. J. Pestic. Sci., 33, 33-39 (2008)
  • Ihara, M., Okajima, T., Yamashita, A., Oda, T., Hirata, K., Nishiwaki, H., Morimoto, T., Akamatsu, M., Ashikawa, Y., Kuroda, S., Mega, R., Kuramitsu, S., Sattelle, D. B., and Matsuda, K.: Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin. Invert. Neurosci., in press (2008)
  • Toshima, K., Kanaoka, S., Yamada, A., Tarumoto, K., Akamatsu, M., Sattelle, D.B., and Matsuda, K.: F Combined roles of loops C and D in the interactions of a neonicotinoid insecticide imidacloprid with the α4β2 nicotinic acetylcholine receptor. Neuropharmacol. 56, 264-272 (2009)
  • Fujikawa, M., Nakao, K., Shimizu, R., and Akamatsu, M.: The usefulness of an artificial membrane accumulation index for estimation of the bioconcentration factor of organophosphorus pesticides. Chemosphere, 74, 751-757 (2009)
  • Nakao, K., Fujikawa, M., Shimizu, R., and Akamatsu, M.: QSAR application for the prediction of compound permeability with in silico descriptors in practical use. J. Comput. Aided Mol Des., 23, 309-319 (2009)
  • Matsuda, K., Kanaoka, S., Akamatsu, M., and Sattelle，D. B.: Diverse actions and target-site selectivity of neonicotinoids: structural insights. Mol. Pharmacol., 76, 1-10 (2009)

  • Ogawa, Y., Akamatsu, M., Hotta, Y., Hosoda, A., Tamura, H.: Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg. Med. Chem. Lett., 20, 2111-2114 (2010)
  • Akamatsu, M.: Importance of physicochemical properties for design of new pesticides. J. Agric. Food Chem., 59, 2909-2917 (2011)
  • Nishiwaki, H., Hasebe, A., Kawaguchi, Y., Akamatsu, M., Shuto. Y., Yamauchi. S.: Larvicidal activity of (-)-dihydroguaiaretic acid derivatives against Culex pipiens. Biosci. Biotechnol. Biochem., 75, 1735-1739 (2011)
  • Nishiwaki, H., Kuriyama, M., Nagaoka, H., Kato, A., Akamatsu, M., Yamauchi, S., Shuto. Y.: Synthesis of imidacloprid derivatives with a chiral alkylated imidazolidine ring and evaluation of their insecticidal activity and affinity to　the nicotinic acetylcholine receptor. Bioorg. Med. Chem., 20, 6305-6312 (2012)
  • Akamatsu, M., Tsujita, K., Pitiyont, V., Saejiew, A., Jiwajinda, S., Tanaka, U: Pesticide residue analyses of soils collected from suburban agricultural fields around Bangkok. Trop. Agr. Develop., 57, 8-15 (2013)
  • Kanaoka, S., Kimura, Y., Fujikawa, M., Nakagawa, Y., Ueda, K., Akamatsu, M.: Substrate recognition by P-glycoprotein efflux transporters: Structure-ATPase activity relationship of diverse chemicals and agrochemicals. J. Pestic. Sci., 38, 112–122 (2013)
  • Ihara,　M., Shimazu, N., Utsunomiya, M., Akamatsu, M., Sattelle, D. B., Matsuda, K.: A single amino acid polymorphism in the wild-type Drosophila melanogaster Dα1 (ALS) subunit strikingly influences agonist efficacy of imidacloprid for Dα1-chicken β2 hybrid nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Biosci. Biotech. Biochem., 78, 543-549 (2014), DOI: 10.1080/09168451.2014.891928.
  • Morishita, C., Minakuchi, C., Yokoi, T., Takimoto, S., Hosoda, A., Akamatsu, M. , Tamura, H., Nakagawa, Y.: cDNA cloning of ecdysone receptor (EcR) and ultraspiracle (USP) from Harmonia axyridis and Epilachna vigintioctopunctata and the evaluation of the binding affinity of ecdysone agonists to the in vitro translated EcR/USP　heterodimers．J. Pestic. Sci., 39, 76-84 (2014)
  • Furutani, S., Ihara, M., Nishino, Y., Akamatsu, M., Jones, A. K., Sattelle, D. B., Matsuda, K.: Exon 3 splicing and mutagenesis identify residues influencing cell surface density of heterologously-expressed silkworm (Bombyx mori) glutamate-gated chloride channels. Mol. Pharmacol., 86, 1-11 (2014), DOI: 10.1124/mol.114.095869
  • Ho Le Quynh Chau, Ho Trung Thong, Nguyen Van Chao, Pham Hoang Son Hung, Vu Van Hai, Le Van An, Fujieda, A., Tanaka, U., Akamatsu, M.: Microbial and Parasitic Contamination on Fresh Vegetables Sold in Traditional Markets in Hue City, Vietnam. J. Food Nut. Res., 2, 959-964 (2014), DOI: 10.12691/jfnr-2-12-16
  • Nagaoka, H., Nishiwaki. H., Kubo, T., Akamatsu, M., Yamauchi, S., Shuto, Y.: Docking model of the nicotinic acetylcholine receptor and nitromethylene neonicotinoid derivatives with a longer chiral substituent and their biological activities. Bioorg. Med. Chem., 23, 759-769 (2015)
  • Shirotani, N., Togawa, M., Ikushiro, S., Sakaki, T., Harada, T., Miyagawa, H., Matsui, M., Nagahori, H., Mikata, K., Nishioka, K., Hirai, N., Akamatsu, M.: Identification and in Silico prediction of metabolites of the model compound, tebufenozide by human CYP3A4 and CYP2C19. Bioorg. Med. Chem., 23, 6594-6601 (2015), DOI:10.1016/j.bmc.2015.09.019.
  • Maeshibu, N., Han, B., Ma, J., Miyahara, K., Torii, K., Ho Tan Duc, Tran Thi Thu Ha, Le Van An, Ho Trung Thong, Akamatsu, M.: Pesticide use and residue in the environment in Hue, Vietnam. Proceeding of the 36th Asian Conference of Remote Sensing, Manila, Phillipines, pp. 62 (2015).
  • Miyata, K., Nakagawa, Y., Kimura, Y., Ueda, K., Akamatsu, M.: In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines. Toxicol. Appl. Pharmacol., 298, 40-47 (2016), doi:10.1016/j.taap.2016.03.008
  • Miyata, K., Nakagawa, Y., Kimura, Y., Ueda, K., Akamatsu, M.: Structure–activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport. Bioorg. Med. Chem., 24, 3184-3191 (2016), doi:10.1016/j.bmc.2016.05.039.

 

International cooperation and overseas activities

International meetings (roles)

  • 20th EuroQSAR, Discovery Informatics & Drug Design (Russia, 1 general paper)
  • 18th EuroQSAR, Discovery Informatics & Drug Design (Greece, Scientific Committee member, 2 general papers)

Educational Activities

On-Campus teaching

  • Graduate level
  • Comparative Study of Resources and Environment
  • Agriculture and Environment in Japan

 

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